Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines

Background and Aims: This study was aimed to investigate the anti-cancer effect of Isochrysis galbana microalgae extract. Methods: In study, chemical composition extract analyzed, its cytotoxic against K562, HL60, U937, MOLT-4, Raji cancer cells investigated. ECV304 endothelial were used as a healthy cell line for understanding selective cytotoxicity. To determine effects extract, an MTT cytotoxicity assay performed. Results: According results experiments, highest shown at about 24.07±6.48% cells. There large number bioactive molecules in extract, these showed specific response when considering synergistic antagonistic on each other. Conclusion: GC-MS analysis most intense content Dodecanoic acid, 3-hydroxy- (CAS) Beta-Hydroxy Acid, Propanoic 2-methyl-, 1-(1,1-dimethylethyl)-2-methyl-1,3-isonide. The investigation specifically is important possible anti-leukemic their combinations that show this line.